Multiple sclerosis (MS) is a disease mainly affecting the central nervous system and the white matter, but findings of gray matter and signs simulating peripheral nerve involvement can also be encountered rarely. In this paper, six patients with peripheral nerve and gray matter findings such as trigeminal neuralgia, oculomotor nerve palsy, peripheral facial palsy (two patients), bilateral symmetrical amyotrophy and lumbar radicular involvement presented. They were all diagnosed as definite multiple sclerosis with their clinical and magnetic resonance imaging (MRI) findings, oligoclonal bands in the cerebrospinal fluid and evoked potential (EP) studies.