It is known that subcortical structures of the dominant hemisphere have an important role in language. Different aphasia forms have been observed depends on lesion localisation on subcortical area. In this study 20 patients with global aphasia were examined. Their CT scan have shown one or more lesions in nucleus caudatus, thalamus, anterior and posterior limbs of internal capsule, globus pallidus, putamen and periventricular white matter. In 12 of 20( 60 %) were shown hematoma or infarct in putamen and periventricular white matter. Our findings suggested that putamen and periventricular white matter in subcortical region were important areas which cause to global aphasia.