The effects of high-dose methylprednisolone on the experimental spinal cord trauma were investigated in this study. The trauma was performed with clip-compression method on the spinal cord of 40 male Wistar rats with T8-T12 total laminectomy. Methylprednisolone (30 mg/kg) was administered intravenously as a bolus injection to twenty rats at 1 hour after trauma, and this group received continously an infusion of methylprednisolone (5.4 mg/kg)in normal saline for 23 hours. Remaining twenty rats untreated. The spinal cords of all rats were removed histopathological evaluation at the end of 24 hours. Methylprednisolone treated rats showed significantly recovery than the untreated rats